Most people experience little to no side effects when starting PrEP. For those who do, common short-term side effects include nausea, headaches, and mild abdominal discomfort. These usually resolve within the first month of use. Rarely, long-term use can affect bone density or kidney function, but these effects are reversible once PrEP is discontinued. Regular monitoring ensures that your health is always prioritized while on PrEP.